I am a certified pediatric nurse practitioner and a fellow of the National Association of Pediatric Nurse Practitioners/Associates. I have a doctorate in nursing from UCLA with my focus of study in immunology and neurobiology of the young infant. My areas of interest and research include immune response, vaccines, SIDS (sudden infant death syndrome), and health maintenance. I have over 40 years of experience in pediatric primary care and have been involved in the education of nurse practitioners for the past 30 years. I have worked at several universities including UCLA, and am currently a professor at Duke University School of Nursing, an affiliate of the Duke Global Health Institute, and a lecturer at University for Developmental Studies in Tamale, Ghana. As the Director of Global Educational Partnerships and Innovation I arrange global clinical experiences for graduate students. In addition to my faculty appointment, I am working on a project to start a Family Nurse Practitioner Program at Kilimanjaro Christian Medical Center in Moshi, Tanzania and am involved in a distance educational project at University for Developmental Studies in Tamale, Ghana.
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Jane E. Blood-Siegfried, PhD, RN, CPNP
Academic Program Affiliations
- Master of Science in Nursing Program
- Doctor of Nursing Practice Program
- PhD - University of California at Los Angeles School of Nursing
- MSN - California State University at Fresno
- BSN - California State University at Fresno
Approximately 70% of infants dying of SIDS have a current upper respiratory tract infection (URI) or have seen their health care provider for symptoms of cough and cold in the weeks before death. Causative mechanisms of SIDS are still unclear. Risk factors for SIDS include exposure to tobacco smoke and prone sleeping, with the most susceptible infants being between 2 and 6 months of age. I am most interested in the role of these risk factors as triggers of SIDS and have been examination their role during the development of autonomic “fight and flight” response in the infant. (If an infant is required to respond to a cardiovascular insult at the wrong time of development then it could be lethal.) My research reflects the hypothesis that upper respiratory infections alter events in the developing immune system, increasing susceptibility to the effects of later infections. A dual infection model of URI and bacterial sepsis is used to elucidate specific immunological events, pathogenesis of the critical infection period, and evaluate cytokines or other immune measures as biomarkers for SIDS risk. Recently, prenatal nicotine exposure has been added to the model, and findings indicate that this exposure increases mortality following normal infectious challenges. Research goals include establishing a mechanism for this synergistic effect, determining the relationship between SIDS death and the timing of infectious stimuli or other immune events, and elucidating the roles of various components of the developing immune system in SIDS.
Awards and Honors
- 2009 || Distinguished Nursing Leader, UCLA, University of California-Los Angeles
- 1995 || Distinguished Dissertation Award, Sigma Theta Tau, UCLA
- 1987 || Inducted, Sigma Theta Tau, Mu Nu Chapter
- 1979 || Fellow, National Association of Pediatric Nurse Associates and Practitioners
Areas of Expertise
- Global and Community Health
- Neonatal Nursing
- Pediatric Nursing
2015 -- PubMed # : 25229995 The Impact of Nurses on Neglected Tropical Disease Management. Public Health Nurs. November, 2015 32(6); 680-701
2015 -- PubMed # : 26212466 Coalition Building for Health: A Community Garden Pilot Project with Apartment Dwelling Refugees. J Community Health Nurs. Jul-Sep, 2015 32(3); 141-50
2015 -- Intra-operative implementation of a tissue sealant on all lung surgery patients: A quality improvement project, Clinical Scholars Review. May 1, 2015 8(1); 125-129
2015 -- PubMed # : 25870597 Animal models for assessment of infection and inflammation: contributions to elucidating the pathophysiology of sudden infant death syndrome. Front Immunol. March, 2015 6 137
2014 -- Help fight Ebola without health risks. News and Observer (Raleigh), p. A9. September 17, 2014
2014 -- Improving anesthetic depth assessment during electroconvulsive therapy with bispectral index monitoring: A pilot quality improvement project Anesthesia eJournal. 2014 2(2);
2014 -- Animal models of sudden infant death syndrome. In Handbook of Laboratory Animal Science edited by Hau, J. and Schapiro, S.. 2014; pp. 127-140. : CRC Press. 2014 127-140
2013 -- PubMed # : 24200295 Increasing HPV vaccination series completion rates via text message reminders. J Pediatr Health Care. November, 2013 28(4); e35-9
2012 -- PubMed # : 22845029 Childhood obesity: Can electronic medical records customized with clinical practice guidelines improve screening and diagnosis? J Am Acad Nurse Pract. August, 2012 24(8); 463-71
2012 -- Online Teaching Guide June 4, 2012
Grant Funding (Selected)
The Effect of Perinatal Nicotine Exposure on the Development of Autonomic ResponsesNational Institutes of Health1K01-NR010910-0108/2008 to 07/2011Role: PI
Project Goal: Investigate the effect of perinatal nicotine exposure on the development of autonomic responses.
CIT Instructional Technology Faculty FellowshipDuke University Center for Instructional Technology07/2010 to 06/2011Role: PI
Project Goal: Group will define and develop “Best Practices” in both technology and pedagogy to be used for teaching online students and mentoring faculty about online education. The work of the Fellowship will be compiled and published as an “Online teaching orientation guide” for current and future faculty member use in the School of Nursing and other schools and programs at Duke.
Effect of maternal nicotine exposure on mortality in suckling rat pups in an infectious model of SIDSDuke University School of Nursing07/2004 to 06/2005Role: PI
Investigate effect of maternal nicotine exposure on mortality in suckling rat pups in an infectious model of SIDS.
Curricular change in online curriculum and technologyDuke University Center for Instructional Technology06/2004 to 05/2005Role: PI
Purpose: A fellowship to support curricular change in online curriculum and technology in the School of Nursing core curriculum. Develop best practices and a rubric for evaluating online coursework.
Partners for Quality EducationRobert Wood Johnson Foundation07/2002 to 06/2004Role: Team member
Partners for Quality Education is a grant to develop an interdisciplinary partnership to provide education for multidisciplinary learners in chronic illness care.
Combined NNP/PNP Program for Rural HealthHealth Resources and Service Administration (HRSA), Division of NursingD09-HP00189-0107/2001 to 06/2004Role: Project Faculty
Three-year grant to educate nurses at the Master’s level in a combined Neonatal Nurse Practitioner/Pediatric Nurse Practitioner pogram for rural health.
Pediatric Acute Care Nurse practitionerHealth Resources and Service Administration (HRSA) Division of Nursing1D23-NU01339-0107/1999 to 06/2002Role: Project faculty
A three year grant to educate nurses at the Master’s level.
Duke-NIEHS Nurse FellowshipNational Institute of Environmental Health Sciences07/1998 to 06/2000Role: PI
Post doctoral research training.
A study of normal cytokine variations in vertically exposed HIV positive and HIV negative infantsUCLA School of Nursing07/1995 to 06/1996Role: PI
Descriptive study of suspected pertussis vaccine injuryUCLA School of Nursing07/1990 to 06/1991Role: PI
DNP alumna Mary "Mimi" Jenko published an article entitled "A systems approach to improving care for all bereaved families" in the Dimensions of Critical Care Nursing. The article was co-authored with Nancy Short.
Jane Blood-Siegfried recently received the Community Service Award from the Checago Bright-Sawo Foundation for her work with Project Liberia Ebola. Blood-Siegfried worked with Liberian Duke nurse Amanda Mathies to provide personal protective equipment (PPE) to Liberia.
Africa has had a hold on Jane Blood-Siegfried, PhD, RN, CPNP, ever since she was a girl, when she lived in Liberia with her family and, among other things, cared for a succession of orphaned baby chimpanzees, one of whom slept in a crib in her room and occasionally clambered up onto her bed and plucked the rollers out of her hair. Her family left Liberia, where her father had been stationed as a U.S. State Department official building schools, when she was
Jane Blood-Siegfried was recently approved as an affiliate of the Duke Global Health Institute (DGHI) for her commitment to global health at Duke. As an affiliate with DGHI, Blood-Siegfried not only had to demonstrate interest in global health, but also participate in a DGHI research, education, service or policy initiative, including mentoring global health majors and minors, or graduate and professional students on fieldwork or research, or teaching a course whose primary departmental designation is global health.
DNP alumna Lynn Eggert along with Donna Biederman, Jane Blood-Siegfried and Mary Champagne published an article entitled "Coalition Building for Health: A Community Garden Pilot Project with Apartment Dwelling Refugees" in the Journal of Community Health Nursing. The project was a part of Eggerts DNP project.
Jane Blood-Siegfried has an article entitled "Animal models for assessment of infection and inflammation: contributions to elucidating the pathophysiology of sudden infant death syndrome (SIDS)" that has been published in Frontiers in Immunology.
Jane Blood-Siegfried, Kathy Pereira and Dean Marion E. Broome presented at a conference sponsored by Duke University School of Nursing and Kilimanjaro Christian Medical University in Arusha, Tanzania, February 9-12. The "Consensus Building Conference: Establishing a Family Nurse Practitioner Program for Rural Tanzania" was attended by the Deputy Minister of Health for Tanzania; stakeholders in Tanzania, Botswana and Ghana; and partners in the U.S. A goal of this conference is to lead the way to establishing a Family Nurse Practitioner program.
Jane Blood-Siegfried, Jennie De Gagne and Brett Morgan received appointments as Adjunct Professors in the University for Development Studies (UDS) School of Medicine and Health Science's Department of Anesthesia. UDS is located in Tamale, Ghana. These two-year faculty appointments are in support of the work being done in association with the Duke Global Health Bass Connections grant that Brett is leading in Ghana.
DUSON faculty members Frank Titch, Chuck Vacchiano and Jane Blood-Siegfried coauthored an article with Dr. Tracey Holsinger from the Durham VA Medical Center entitled "Improving anesthetic depth assessment during electroconvulsive therapy with bispectral index monitoring: A pilot quality improvement project" that has been published by Anesthesia eJournal.