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Jane E. Blood-Siegfried, PhD, RN, CPNP

(919) 668-3837
3063 Pearson Building

I am a certified pediatric nurse practitioner and a fellow of the National Association of Pediatric Nurse Practitioners/Associates. I have a doctorate in nursing from UCLA with my focus of study in immunology and neurobiology of the young infant. My areas of interest and research include immune response, vaccines, SIDS (sudden infant death syndrome), and health maintenance. I have over 40 years of experience in pediatric primary care and have been involved in the education of nurse practitioners for the past 30 years. I have worked at several universities including UCLA, and am currently a professor at Duke University School of Nursing, an affiliate of the Duke Global Health Institute, and a lecturer at University for Developmental Studies in Tamale, Ghana. As the Director of Global Educational Partnerships and Innovation I arrange global clinical experiences for graduate students. In addition to my faculty appointment, I am working on a project to start a Family Nurse Practitioner Program at Kilimanjaro Christian Medical Center in Moshi, Tanzania and am involved in a distance educational project at University for Developmental Studies in Tamale, Ghana.

Academic Program Affiliations

  • Master of Science in Nursing Program
  • Doctor of Nursing Practice Program


  • PhD - University of California at Los Angeles School of Nursing
  • MSN - California State University at Fresno
  • BSN - California State University at Fresno

Research Interests

Approximately 70% of infants dying of SIDS have a current upper respiratory tract infection (URI) or have seen their health care provider for symptoms of cough and cold in the weeks before death. Causative mechanisms of SIDS are still unclear. Risk factors for SIDS include exposure to tobacco smoke and prone sleeping, with the most susceptible infants being between 2 and 6 months of age. I am most interested in the role of these risk factors as triggers of SIDS and have been examination their role during the development of autonomic “fight and flight” response in the infant. (If an infant is required to respond to a cardiovascular insult at the wrong time of development then it could be lethal.) My research reflects the hypothesis that upper respiratory infections alter events in the developing immune system, increasing susceptibility to the effects of later infections. A dual infection model of URI and bacterial sepsis is used to elucidate specific immunological events, pathogenesis of the critical infection period, and evaluate cytokines or other immune measures as biomarkers for SIDS risk. Recently, prenatal nicotine exposure has been added to the model, and findings indicate that this exposure increases mortality following normal infectious challenges. Research goals include establishing a mechanism for this synergistic effect, determining the relationship between SIDS death and the timing of infectious stimuli or other immune events, and elucidating the roles of various components of the developing immune system in SIDS.

Awards and Honors

  • 2009 || Distinguished Nursing Leader, UCLA, University of California-Los Angeles
  • 1995 || Distinguished Dissertation Award, Sigma Theta Tau, UCLA
  • 1987 || Inducted, Sigma Theta Tau, Mu Nu Chapter
  • 1979 || Fellow, National Association of Pediatric Nurse Associates and Practitioners

Areas of Expertise

  • Global and Community Health
  • Neonatal Nursing
  • Pediatric Nursing

Representative Publications

  • 2015 -- PubMed # : 25229995 Blood-Siegfried, J. and Zeantoe, G. C. and Evans, L. J. and Bondo, J. and Forstner, J. R. and Wood, K. The Impact of Nurses on Neglected Tropical Disease Management. Public Health Nurs. November, 2015 32(6); 680-701
  • 2015 -- PubMed # : 26212466 Eggert, L. K. and Blood-Siegfried, J. and Champagne, M. and Al-Jumaily, M. and Biederman, D. J. Coalition Building for Health: A Community Garden Pilot Project with Apartment Dwelling Refugees. J Community Health Nurs. Jul-Sep, 2015 32(3); 141-50
  • 2015 -- Cain, S. and Anderson, R. and Stockert, P. and Brown, S. and Blood-Siegfried, J. Intra-operative implementation of a tissue sealant on all lung surgery patients: A quality improvement project, Clinical Scholars Review. May 1, 2015 8(1); 125-129
  • 2015 -- PubMed # : 25870597 Blood-Siegfried, J. Animal models for assessment of infection and inflammation: contributions to elucidating the pathophysiology of sudden infant death syndrome. Front Immunol. March, 2015 6 137
  • 2014 -- Blood-Siegfried, J. E. Help fight Ebola without health risks. News and Observer (Raleigh), p. A9. September 17, 2014
  • 2014 -- Titch, J. F. and Holsinger, T. and Vacchiano, C., and Blood-Siegfried, J. Improving anesthetic depth assessment during electroconvulsive therapy with bispectral index monitoring: A pilot quality improvement project Anesthesia eJournal. 2014 2(2);
  • 2014 -- Blood-Siegfried, J.. Animal models of sudden infant death syndrome. In Handbook of Laboratory Animal Science edited by Hau, J. and Schapiro, S.. 2014; pp. 127-140. : CRC Press. 2014 127-140
  • 2013 -- PubMed # : 24200295 Matheson, E. C. and Derouin, A. and Gagliano, M. and Thompson, J. A. and Blood-Siegfried, J. Increasing HPV vaccination series completion rates via text message reminders. J Pediatr Health Care. November, 2013 28(4); e35-9
  • 2012 -- PubMed # : 22845029 Saviñon, C. and Taylor, J. S. and Canty-Mitchell, J. and Blood-Siegfried, J. Childhood obesity: Can electronic medical records customized with clinical practice guidelines improve screening and diagnosis? J Am Acad Nurse Pract. August, 2012 24(8); 463-71
  • 2012 -- Blood-Siegfried, J. and Hawks, S. and Nevidjon, B. and Phillips, B. and Short, N. and Valiga, T. and Vorderstrasse, A. and Wood, K.. and Conrad, R. M. Online Teaching Guide June 4, 2012


Grant Funding (Selected)

  • The Effect of Perinatal Nicotine Exposure on the Development of Autonomic Responses

    National Institutes of Health
    08/2008 to 07/2011
    Role: PI

    Project Goal: Investigate the effect of perinatal nicotine exposure on the development of autonomic responses.

  • CIT Instructional Technology Faculty Fellowship

    Duke University Center for Instructional Technology
    07/2010 to 06/2011
    Role: PI

    Project Goal: Group will define and develop “Best Practices” in both technology and pedagogy to be used for teaching online students and mentoring faculty about online education. The work of the Fellowship will be compiled and published as an “Online teaching orientation guide” for current and future faculty member use in the School of Nursing and other schools and programs at Duke.

  • Effect of maternal nicotine exposure on mortality in suckling rat pups in an infectious model of SIDS

    Duke University School of Nursing
    07/2004 to 06/2005
    Role: PI

    Investigate effect of maternal nicotine exposure on mortality in suckling rat pups in an infectious model of SIDS.

  • Curricular change in online curriculum and technology

    Duke University Center for Instructional Technology
    06/2004 to 05/2005
    Role: PI

    Purpose: A fellowship to support curricular change in online curriculum and technology in the School of Nursing core curriculum. Develop best practices and a rubric for evaluating online coursework.

  • Partners for Quality Education

    Robert Wood Johnson Foundation
    07/2002 to 06/2004
    Role: Team member

    Partners for Quality Education is a grant to develop an interdisciplinary partnership to provide education for multidisciplinary learners in chronic illness care.

  • Combined NNP/PNP Program for Rural Health

    Health Resources and Service Administration (HRSA), Division of Nursing
    07/2001 to 06/2004
    Role: Project Faculty

    Three-year grant to educate nurses at the Master’s level in a combined Neonatal Nurse Practitioner/Pediatric Nurse Practitioner pogram for rural health.

  • Pediatric Acute Care Nurse practitioner

    Health Resources and Service Administration (HRSA) Division of Nursing
    07/1999 to 06/2002
    Role: Project faculty

    A three year grant to educate nurses at the Master’s level.

  • Duke-NIEHS Nurse Fellowship

    National Institute of Environmental Health Sciences
    07/1998 to 06/2000
    Role: PI

    Post doctoral research training.

  • A study of normal cytokine variations in vertically exposed HIV positive and HIV negative infants

    UCLA School of Nursing
    07/1995 to 06/1996
    Role: PI
  • Descriptive study of suspected pertussis vaccine injury

    UCLA School of Nursing
    07/1990 to 06/1991
    Role: PI
Friday, April 28, 2017

Jane Blood-Siegfried and Katherine Pereira recently published an article entitled "Descriptive Study of Nursing Scope of Practice in Rural Medically Underserved Areas of Africa, South of the Sahara" in the International Journal of Africa Nursing Sciences. Co-authors included experts from the Kilimanjaro Christian medical University College Faculty of Nursing in Tanzania.

Wednesday, December 7, 2016

DNP alumna Mary "Mimi" Jenko published an article entitled "A systems approach to improving care for all bereaved families" in the Dimensions of Critical Care Nursing. The article was co-authored with Nancy Short.

Tuesday, December 6, 2016

Jane Blood-Siegfried recently received the Community Service Award from the Checago Bright-Sawo Foundation for her work with Project Liberia Ebola. Blood-Siegfried worked with Liberian Duke nurse Amanda Mathies to provide personal protective equipment (PPE) to Liberia.

Friday, April 29, 2016

Jane Blood-Siegfried recently joined six other Duke professors in becoming faculty members for Duke Global Health Institute (DGHI).  Learn more here.

Monday, October 26, 2015

Africa has had a hold on Jane Blood-Siegfried, PhD, RN, CPNP, ever since she was a girl, when she lived in Liberia with her family and, among other things, cared for a succession of orphaned baby chimpanzees, one of whom slept in a crib in her room and occasionally clambered up onto her bed and plucked the rollers out of her hair. Her family left Liberia, where her father had been stationed as a U.S. State Department official building schools, when she was

Friday, October 9, 2015

Jane Blood-Siegfried was recently approved as an affiliate of the Duke Global Health Institute (DGHI) for her commitment to global health at Duke. As an affiliate with DGHI, Blood-Siegfried not only had to demonstrate interest in global health, but also participate in a DGHI research, education, service or policy initiative, including mentoring global health majors and minors, or graduate and professional students on fieldwork or research, or teaching a course whose primary departmental designation is global health.

Thursday, July 30, 2015

DNP alumna Lynn Eggert along with Donna Biederman, Jane Blood-Siegfried and Mary Champagne published an article entitled "Coalition Building for Health: A Community Garden Pilot Project with Apartment Dwelling Refugees" in the Journal of Community Health Nursing. The project was a part of Eggerts DNP project.

Friday, March 13, 2015

Jane Blood-Siegfried, Kathy Pereira and Dean Marion E. Broome presented at a conference sponsored by Duke University School of Nursing and Kilimanjaro Christian Medical University in Arusha, Tanzania, February 9-12. The "Consensus Building Conference: Establishing a Family Nurse Practitioner Program for Rural Tanzania" was attended by the Deputy Minister of Health for Tanzania; stakeholders in Tanzania, Botswana and Ghana; and partners in the U.S. A goal of this conference is to lead the way to establishing a Family Nurse Practitioner program.

Friday, February 6, 2015

Jane Blood-Siegfried, Jennie De Gagne and Brett Morgan received appointments as Adjunct Professors in the University for Development Studies (UDS) School of Medicine and Health Science's Department of Anesthesia. UDS is located in Tamale, Ghana. These two-year faculty appointments are in support of the work being done in association with the Duke Global Health Bass Connections grant that Brett is leading in Ghana.