James (Les) L. Harmon, DNP, RN, ANP-BC, AAHIVS

Les Harmon came to nursing as a second career and has focused his work on treating and improving the quality of life for people living with HIV/AIDS for more than twenty years. He earned a Bachelor’s degree in architecture from the University of North Carolina-Charlotte in 1977, and later moved to San Francisco, where he worked in architectural design, graphic design, mapmaking, and medical illustration. In 1991 he earned a Bachelor’s degree in nursing from the University of San Francisco’s accelerated BSN program. In 1997 he earned a Master’s degree in nursing from Duke, and that same year helped start the Northern Outreach Clinic in Henderson, NC, where he continues to maintain a clinical practice with HIV/AIDS patients. He joined the school’s regular rank faculty in 2008 and earned a DNP from Duke University in 2012.


As a faculty member, he teaches in the Nurse Practitioner Program; he is Lead Faculty for the AGNP program and is the director of the HIV/AIDS concentration. Also at Duke, he has worked as a research assistant and coordinator for a number of clinical research projects, most recently with Dr. Julie Barroso and her HIV-related fatigue research. Dr. Harmon maintains certification as an Adult Nurse Practitioner through the American Nurses Credentialing Center, and as an HIV Specialist through the American Academy of HIV Medicine.

Academic Program Affiliations
  • Master of Science in Nursing Program
Education
  • DNP - Duke University School of Nursing
  • MSN - Duke University School of Nursing
Research Interests
HIV/AIDS
Awards and Honors
  • 2014 || JANAC Article of the Year Award, Association of Nurses in AIDS Care (ANAC)
  • 2010 || Inducted, Sigma Theta Tau International, Beta Epsilon Chapter
  • 2008 || Ten Year HIV/AIDS Service Award, Northern Outreach Clinic, Henderson, NC
  • 2004 || Anemia Case Study Award, Association of Nurses in AIDS Care (ANAC)
  • 2004 || Volunteer Award, North Carolina Governor's World AIDS Day
  • 2001 || Nurse Research Mentor Award, Duke Friends of Nursing
Areas of Interest
Medical Management of Adults with HIV/AIDS
Representative Publications
  • 2010 -- PubMed # : 20352317 -- Barroso, J. and Hammill, B. G. and Leserman, J. and Salahuddin, N. and Harmon, J. L. and Pence, B. W. Physiological and psychosocial factors that predict HIV-related fatigue. AIDS Behav. March, 2010 14(6); 1415-27. PMC2975810
  • 2009 -- PubMed # : 19281346 -- Pence, B. W. and Barroso, J. and Harmon, J. L. and Leserman, J. and Salahuddin, N. and Hammill, B. G. Chronicity and remission of fatigue in patients with established HIV infection. AIDS Patient Care STDS. April, 2009 23(4); 239-44. PMC2856568
  • 2009 -- PubMed # : 19118766 -- Salahuddin, N. and Barroso, J. and Leserman, J. and Harmon, J. L. and Pence, B. W. Daytime sleepiness, nighttime sleep quality, stressful life events, and HIV-related fatigue. J Assoc Nurses AIDS Care. March, 2009 20(1); 6-13. PMC2630408
  • 2008 -- PubMed # : 18328959 -- Harmon, J. L. and Barroso, J. and Pence, B. W. and Leserman, J. and Salahuddin, N. Demographic and illness-related variables associated with HIV-related fatigue. J Assoc Nurses AIDS Care. May, 2008 19(2); 90-7. PMC2287376
  • 2008 -- PubMed # : 18184975 -- Barroso, J. and Pence, B. W. and Salahuddin, N. and Harmon, J. L. and Leserman, J. Physiological correlates of HIV-related fatigue. Clin Nurs Res. February, 2008 17(1); 5-19. PMC2426776
  • 2000 -- PubMed # : 10772526 -- Markert, M. L. and Hicks, C. B. and Bartlett, J. A. and Harmon, J. L. and Hale, L. P. and Greenberg, M. L. and Ferrari, G. and Ottinger, J. and Boeck, A. and Kloster, A. L. and McLaughlin, T. M. and Bleich, K. B. and Ungerleider, R. M. and Lyerly, H. K. and Wilkinson, W. E. and Rousseau, F. S. and Heath-Chiozzi, M. E. and Leonard, J. M. and Haase, A. T. and Shaw, G. M. and Bucy, R. P. and Douek, D. C. and Koup, R. A. and Haynes, B. F. and Bolognesi, D. P. and Weinhold, K. J. Effect of highly active antiretroviral therapy and thymic transplantation on immunoreconstitution in HIV infection. AIDS Res Hum Retroviruses. March, 2000 16(5); 403-13.
  • 2011 -- Harmon, J. L. The next steps to take against AIDS [opinion/editorial] The News and Observer (Raleigh, NC). November 13, 2011 .
  • 2008 -- PubMed # : 18608079 -- Leserman, J. and Barroso, J. and Pence, B. W. and Salahuddin, N. and Harmon, J. L. Trauma, stressful life events and depression predict HIV-related fatigue. AIDS Care. November, 2008 20(10); 1258-65.
  • 2008 -- PubMed # : 18608084 -- Pence, B. W. and Barroso, J. and Leserman, J. and Harmon, J. L. and Salahuddin, N. Measuring fatigue in people living with HIV/AIDS: psychometric characteristics of the HIV-related fatigue scale. AIDS Care. August, 2008 20(7); 829-37.
  • 2013 -- Rogalski, J. Serving the suffering - HIV/AIDS research and care. Duke Nursing Magazine. Winter, 2013 9(1); 22-24.
  • 2011 -- Harmon, J. L. and McAllaster, C. HIV/AIDS in the South: A Call to Action. November 22, 2011 .
  • 2013 -- PubMed # : 23582578 -- Harmon, J. L. and Collins-Ogle, M. and Bartlett, J. A. and Thompson, J. and Barroso, J. Integrating Routine HIV Screening Into a Primary Care Setting in Rural North Carolina. J Assoc Nurses AIDS Care. January-February, 2014 25(1); 70-82.
  • 2014 -- PubMed # : 23814175 -- Barroso, J. and Harmon, J. L. and Madison, J. L. and Pence, B. W. Intensity, chronicity, circumstances, and consequences of HIV-related fatigue: a longitudinal study. Clin Nurs Res. October, 2014 23(5); 514-28. PMC3867537
  • 2015 -- PubMed # : 26061807 -- Caiola, C. and McGee, K. and Harmon, J. L. Reflections: A Case for Intersectional Approaches in HIV Research. AIDS Res Hum Retroviruses. July, 2015 31(7); 669-70.
  • 2015 -- PubMed # : 25701691 -- Barroso, J. and Leserman, J. and Harmon, J. L. and Hammill, B. and Pence, B. W. Fatigue in HIV-Infected People: A Three-Year Observational Study. J Pain Symptom Manage. July, 2015 50(1); 69-79.
Grant Funding (Selected)
  • HIV Nurse Practitioner Training Program
    Health Resources and Service Administration
    1H4A-HA26219-01-00
    07/2013 to 06/2017
    Project goal: Development of an HIV/AIDS concentration for nurse practitioners in the MSN program.
  • HIV-Related Fatigue Study
    National Institutes of Health, National Institute of Nursing Research
    R01-NR008681
    01/2004 to 01/2009
    Role: Research Assistant
    Project Goal: To better understand fatigue in HIV-positive people and identify predictors of its occurrence and change, we propose to conduct a prospective, longitudinal study to address three aims: 1) to determine the level, circumstances, and consequences of fatigue in a group of community-dwelling HIV-positive individuals; 2) to determine at baseline the relationship of personal, HIV-related, physiological, psychosocial, and sleep quality variables to fatigue in HIV-positive individuals; and 3) to determine prospectively the relationship of personal and HIV-related variables, and changes in physiological, psychosocial, and sleep quality variables to chronicity of fatigue (percentage of visits fatigued, level of fatigue over time) in HIV-positive individuals.
  • A Phase I Dose Escalation Trial to Evaluate the Safety, Pharmacokinetics, and Antiviral Activity of T-1249 in HIV-1 Infected Adults
    Trimeris, Inc.
    T-1249-101
    02/2001 to 12/2001
    Role: Study Coordinator
    Project Goal: To evaluate the safety, pharmacokinetics and antiviral activity of T-1249.
  • An Open Label Extension Study for Patients who have Participated in an Emivirine Protocol
    Triangle Pharmaceuticals
    MKC-501
    01/2000 to 12/2001
    Role: Study Coordinator
    Project Goal: Evaluate the long term safety and efficacy of Emivirine.
  • Phase I/II Study of ABT-378/Ritonavir in Combination with Reverse Transcriptase Inhibitors in Antiretroviral-Naïve HIV-Infected Subjects
    Abbott Pharmaceuticals
    M97-720
    10/1997 to 01/2005
    Role: Study Coordinator
    Project Goal: Evaluate the safety and efficacy of a new protease inhibitor.
  • SPIRATS-C: A Pilot Study of the Impact of Combined Antiretroviral Therapy and Thymus Transplantation on Viral Dynamics and Immunologic Reconstruction in HIV Infected Patients
    Abbott Pharmaceuticals
    07/1996 to 12/1997
    Role: Study Coordinator
    Project Goal: Analysis of the impact of combined antiretroviral therapy and thymus transplantation on the viral dynamics and the immunologic reconstruction in subjects with HIV-1 infection.
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