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James (Les) L. Harmon, DNP, RN, ANP-BC, AAHIVS

Associate Professor
(919) 681-4846
3015 Pearson Building

Les Harmon came to nursing as a second career and has focused his work on treating and improving the quality of life for people living with HIV/AIDS for more than twenty years. He earned a Bachelor’s degree in architecture from the University of North Carolina-Charlotte in 1977, and later moved to San Francisco, where he worked in architectural design, graphic design, mapmaking, and medical illustration. In 1991 he earned a Bachelor’s degree in nursing from the University of San Francisco’s accelerated BSN program. In 1997 he earned a Master’s degree in nursing from Duke, and that same year helped start the Northern Outreach Clinic in Henderson, NC, where he continues to maintain a clinical practice with HIV/AIDS patients. He joined the school’s regular rank faculty in 2008 and earned a DNP from Duke University in 2012.

As a faculty member, he teaches in the Nurse Practitioner Program; he is Lead Faculty for the AGNP program and is the director of the HIV/AIDS concentration. Also at Duke, he has worked as a research assistant and coordinator for a number of clinical research projects, most recently with Dr. Julie Barroso and her HIV-related fatigue research. Dr. Harmon maintains certification as an Adult Nurse Practitioner through the American Nurses Credentialing Center, and as an HIV Specialist through the American Academy of HIV Medicine.

Academic Program Affiliations

  • Master of Science in Nursing Program


  • DNP - Duke University School of Nursing
  • MSN - Duke University School of Nursing

Research Interests


Awards and Honors

  • 2014 || JANAC Article of the Year Award, Association of Nurses in AIDS Care (ANAC)
  • 2010 || Inducted, Sigma Theta Tau International, Beta Epsilon Chapter
  • 2008 || Ten Year HIV/AIDS Service Award, Northern Outreach Clinic, Henderson, NC
  • 2004 || Anemia Case Study Award, Association of Nurses in AIDS Care (ANAC)
  • 2004 || Volunteer Award, North Carolina Governor's World AIDS Day
  • 2001 || Nurse Research Mentor Award, Duke Friends of Nursing

Areas of Expertise

  • Acute / Critical Care
  • Chronic Illness

Areas of Interest

Medical Management of Adults with HIV/AIDS

Representative Publications

  • 2015 -- PubMed # : 26061807 Caiola, C. and McGee, K. and Harmon, J. L. Reflections: A Case for Intersectional Approaches in HIV Research. AIDS Res Hum Retroviruses. July, 2015 31(7); 669-70
  • 2015 -- PubMed # : 25701691 Barroso, J. and Leserman, J. and Harmon, J. L. and Hammill, B. and Pence, B. W. Fatigue in HIV-Infected People: A Three-Year Observational Study. J Pain Symptom Manage. July, 2015 50(1); 69-79
  • 2014 -- PubMed # : 23814175 Barroso, J. and Harmon, J. L. and Madison, J. L. and Pence, B. W. Intensity, chronicity, circumstances, and consequences of HIV-related fatigue: a longitudinal study. Clin Nurs Res. October, 2014 23(5); 514-28 PMC3867537
  • 2013 -- Rogalski, J. Serving the suffering - HIV/AIDS research and care. Duke Nursing Magazine. Winter, 2013 9(1); 22-24
  • 2013 -- PubMed # : 23582578 Harmon, J. L. and Collins-Ogle, M. and Bartlett, J. A. and Thompson, J. and Barroso, J. Integrating Routine HIV Screening Into a Primary Care Setting in Rural North Carolina. J Assoc Nurses AIDS Care. January-February, 2014 25(1); 70-82
  • 2011 -- Harmon, J. L. and McAllaster, C. HIV/AIDS in the South: A Call to Action. November 22, 2011
  • 2011 -- Harmon, J. L. The next steps to take against AIDS [opinion/editorial] The News and Observer (Raleigh, NC). November 13, 2011
  • 2010 -- PubMed # : 20352317 Barroso, J. and Hammill, B. G. and Leserman, J. and Salahuddin, N. and Harmon, J. L. and Pence, B. W. Physiological and psychosocial factors that predict HIV-related fatigue. AIDS Behav. March, 2010 14(6); 1415-27 PMC2975810
  • 2009 -- PubMed # : 19281346 Pence, B. W. and Barroso, J. and Harmon, J. L. and Leserman, J. and Salahuddin, N. and Hammill, B. G. Chronicity and remission of fatigue in patients with established HIV infection. AIDS Patient Care STDS. April, 2009 23(4); 239-44 PMC2856568
  • 2009 -- PubMed # : 19118766 Salahuddin, N. and Barroso, J. and Leserman, J. and Harmon, J. L. and Pence, B. W. Daytime sleepiness, nighttime sleep quality, stressful life events, and HIV-related fatigue. J Assoc Nurses AIDS Care. March, 2009 20(1); 6-13 PMC2630408


Grant Funding (Selected)

  • HIV Nurse Practitioner Training Program

    Health Resources and Service Administration
    07/2013 to 06/2017

    Project goal: Development of an HIV/AIDS concentration for nurse practitioners in the MSN program.

  • HIV-Related Fatigue Study

    National Institutes of Health, National Institute of Nursing Research
    01/2004 to 01/2009
    Role: Research Assistant

    Project Goal: To better understand fatigue in HIV-positive people and identify predictors of its occurrence and change, we propose to conduct a prospective, longitudinal study to address three aims: 1) to determine the level, circumstances, and consequences of fatigue in a group of community-dwelling HIV-positive individuals; 2) to determine at baseline the relationship of personal, HIV-related, physiological, psychosocial, and sleep quality variables to fatigue in HIV-positive individuals; and 3) to determine prospectively the relationship of personal and HIV-related variables, and changes in physiological, psychosocial, and sleep quality variables to chronicity of fatigue (percentage of visits fatigued, level of fatigue over time) in HIV-positive individuals.

  • A Phase I Dose Escalation Trial to Evaluate the Safety, Pharmacokinetics, and Antiviral Activity of T-1249 in HIV-1 Infected Adults

    Trimeris, Inc.
    02/2001 to 12/2001
    Role: Study Coordinator

    Project Goal: To evaluate the safety, pharmacokinetics and antiviral activity of T-1249.

  • An Open Label Extension Study for Patients who have Participated in an Emivirine Protocol

    Triangle Pharmaceuticals
    01/2000 to 12/2001
    Role: Study Coordinator

    Project Goal: Evaluate the long term safety and efficacy of Emivirine.

  • Phase I/II Study of ABT-378/Ritonavir in Combination with Reverse Transcriptase Inhibitors in Antiretroviral-Naïve HIV-Infected Subjects

    Abbott Pharmaceuticals
    10/1997 to 01/2005
    Role: Study Coordinator

    Project Goal: Evaluate the safety and efficacy of a new protease inhibitor.

  • SPIRATS-C: A Pilot Study of the Impact of Combined Antiretroviral Therapy and Thymus Transplantation on Viral Dynamics and Immunologic Reconstruction in HIV Infected Patients

    Abbott Pharmaceuticals
    07/1996 to 12/1997
    Role: Study Coordinator

    Project Goal: Analysis of the impact of combined antiretroviral therapy and thymus transplantation on the viral dynamics and the immunologic reconstruction in subjects with HIV-1 infection.

Thursday, December 21, 2017

Les Harmon was recently recognized by the state of North Carolina at a World AIDS Day celebration and Vigil for Hope honoring long term HIV providers and survivors. The event, sponsored by the NC Division of Public Health Communicable Disease Branch, was held on Dec. 8 at the NC Museum of History in Raleigh. Harmon has provided primary medical care to people at HIV at the Norther Outreach Clinic in Henderson, NC for the past 20 years.

Wednesday, September 20, 2017

Les Harmon was an invited speaker at the 13th annual Fall Scientific Retreat of The Duke Cancer for AIDS Research held at Duke on Sept. 18. Harmon gave a podium presentation entitled "The HIV Specialty for Nurse Practitioners at the Duke University School of Nursing."

Thursday, August 10, 2017

Kara McGee and Les Harmon recently presented a poster at the 9th International AIDS Society Conference on HIV Science in Paris, France. The poster presentation entitled "Workforce Development with an Innovative HIV Training Program for Nurse Practitioners" featured the HIV specialty for nurse practitioners at DUSON.

Wednesday, November 30, 2016

Ever since the outbreak of the AIDS epidemic in 1981, many medical professionals, community activists and others have been fighting to prevent new HIV infections, diagnose existing ones and care for people living with HIV/AIDS. On December 1, people around the world will unite in the fight against HIV/AIDS under this year’s theme for World AIDS Day: “Leadership. Commitment. Impact.”

Friday, May 6, 2016

James "Les" Harmon served as the guest editor for the May/June issue of the Journal of the Association of Nurses in AIDS Care, which is a special issue on workforce development related to HIV/AIDS.

Also included in this issue are two publications written by DUSON faculty and staff:

Michael Relf and Harmon co-authored an article entitled "Entry-level competencies required of primary care nurse practitioners providing HIV specialty care: A national practice validation study."

Wednesday, December 3, 2014

On the heels of the 26th annual World AIDS Day, we may ask ourselves what has been achieved in the three decades since the epidemic first began. According to the AIDS Community Research Initiative of America, “Nearly half of all Americans with HIV live in the South, with prevalence rates in Georgia, Florida, and Louisiana now at 200 per 100,000 people—a rate surpassed in the U.S. only by the heavily populated Northeast.

Monday, December 1, 2014

At the annual conference of the Association of Nurses in AIDS Care (ANAC) in Miami, Fla., this November:

Friday, July 25, 2014
Les Harmon has published an article entitled "Integrating routine HIV screening into a primary care setting in rural North Carolina" in the Journal of the Association of Nurses in AIDS Care. Additionally, the Association of Nurses in AIDS Care (ANAC) selected his article as one of two ANAC 2014 recipients of the JANAC Article of the Year Award.
Monday, April 1, 2013

(From Winter 2013 Duke Nursing magazine)

By Jim Rogalski

For Julie Barroso, it was watching a dietary aid cautiously push a food tray into an AIDS patient’s room with her foot.

For James “Les” Harmon, it was the compassion of caregivers he witnessed while volunteering at an AIDS hospice in San Francisco.

Friday, December 7, 2012

At the Association of Nurses in AIDS Care 25th Anniversary Annual Conference in Tucson, Arizona, November 15-17, Julie Barroso and Michael Relf as invited speakers presented "HIV-Related Stigma: What Has Changes in the Past 30 Years?"; Julie Barroso led a pre-conference session entitled "Conducting Qualitative Research: An Overview"; and Les Harmon gave an oral presentation entitled "Integrating Routine HIV Screening into a Primary Care Setting in Rural North Carolina." A poster abstract co-authored by PhD student Joyell Arscott entitled "Transitioning Youth to Adult Care through Project AC