Jane E. Blood-Siegfried, PhD, RN, CPNP

I am a certified pediatric nurse practitioner and a fellow of the National Association of Pediatric Nurse Practitioners/Associates. I have a doctorate in nursing from UCLA with my focus of study in immunology and neurobiology of the young infant. My areas of interest and research include immune response, vaccines, SIDS (sudden infant death syndrome), and health maintenance. I have over 40 years of experience in pediatric primary care and have been involved in the education of nurse practitioners for the past 30 years. I have worked at several universities including UCLA, and am currently a professor at Duke University School of Nursing, an affiliate of the Duke Global Health Institute, and a lecturer at University for Developmental Studies in Tamale, Ghana. As the Director of Global Educational Partnerships and Innovation I arrange global clinical experiences for graduate students. In addition to my faculty appointment, I am working on a project to start a Family Nurse Practitioner Program at Kilimanjaro Christian Medical Center in Moshi, Tanzania and am involved in a distance educational project at University for Developmental Studies in Tamale, Ghana.

Academic Program Affiliations
  • Master of Science in Nursing Program
  • Doctor of Nursing Practice Program
  • PhD - University of California at Los Angeles School of Nursing
  • MSN - California State University at Fresno
  • BSN - California State University at Fresno
Research Interests

Approximately 70% of infants dying of SIDS have a current upper respiratory tract infection (URI) or have seen their health care provider for symptoms of cough and cold in the weeks before death. Causative mechanisms of SIDS are still unclear. Risk factors for SIDS include exposure to tobacco smoke and prone sleeping, with the most susceptible infants being between 2 and 6 months of age. I am most interested in the role of these risk factors as triggers of SIDS and have been examination their role during the development of autonomic “fight and flight” response in the infant. (If an infant is required to respond to a cardiovascular insult at the wrong time of development then it could be lethal.) My research reflects the hypothesis that upper respiratory infections alter events in the developing immune system, increasing susceptibility to the effects of later infections. A dual infection model of URI and bacterial sepsis is used to elucidate specific immunological events, pathogenesis of the critical infection period, and evaluate cytokines or other immune measures as biomarkers for SIDS risk. Recently, prenatal nicotine exposure has been added to the model, and findings indicate that this exposure increases mortality following normal infectious challenges. Research goals include establishing a mechanism for this synergistic effect, determining the relationship between SIDS death and the timing of infectious stimuli or other immune events, and elucidating the roles of various components of the developing immune system in SIDS.

Awards and Honors
  • 2009 || Distinguished Nursing Leader, UCLA, University of California-Los Angeles
  • 1995 || Distinguished Dissertation Award, Sigma Theta Tau, UCLA
  • 1987 || Inducted, Sigma Theta Tau, Mu Nu Chapter
  • 1979 || Fellow, National Association of Pediatric Nurse Associates and Practitioners
Representative Publications
  • 2008 -- Blood-Siegfried, J. Boils. 2008 346-347.
  • 2007 -- Blood-Siegfried, J. Animal models of sudden unexplained death. 2007; revised 2011 583-590.
  • 2010 -- Blood-Siegfried, J. Alport Syndrome. May, 2010 36-37.
  • 2010 -- Blood-Siegfried, J. Cediak Higashi Syndrome. May, 2010 219-221.
  • 2010 -- PubMed # : 20189133 -- Blood-Siegfried, J. and Rende, E. K. The long-term effects of prenatal nicotine exposure on neurologic development. J Midwifery Womens Health. March-April, 2010 55(2); 143-52. PMC2998347
  • 2009 -- PubMed # : 19114412 -- Blood-Siegfried, J. and Bowers, M. T. and Lorimer, M. Is shock a key element in the pathology of sudden infant death syndrome (SIDS)? Biol Res Nurs. October, 2009 11(2); 187-94. PMC2989240
  • 2009 -- PubMed # : 19874217 -- Blood-Siegfried, J. The role of infection and inflammation in sudden infant death syndrome. Immunopharmacol Immunotoxicol. December, 2009 31(4); 516-23. PMC2999632
  • 2008 -- PubMed # : 18562573 -- Blood-Siegfried, J. and Rambaud, C. and Nyska, A. and Germolec, D. R. Evidence for infection, inflammation and shock in sudden infant death: parallels between a neonatal rat model of sudden death and infants who died of sudden infant death syndrome. Innate Immun. 14(3); 145-52. PMC2679510
  • 2008 -- PubMed # : 18976231 -- Blood-Siegfried, J. E. and Short, N. M. and Rapp, C. G. and Hill, E. and Talbert, S. and Skinner, J. and Campbell, A. and Goodwin, L. A rubric for improving the quality of online courses. Int J Nurs Educ Scholarsh. September, 2008 5 Article 34.
  • 2006 -- Blood-Siegfried, J. and Lieder, H. and Deary, K. To screen or not to screen: the complexities of newborn screening in the 21st century. Journal for Nurse Practitioners. May, 2006 2(5); 300-308.
  • 2004 -- PubMed # : 15325401 -- Blood-Siegfried, J. and Nyska, A. and Geisenhoffer, K. and Lieder, H. and Moomaw, C. and Cobb, K. and Shelton, B. and Coombs, W. and Germolec, D. Alteration in regulation of inflammatory response to influenza a virus and endotoxin in suckling rat pups: a potential relationship to sudden infant death syndrome. FEMS Immunol Med Microbiol. 42(1); 85-93.
  • 2004 -- PubMed # : 15325395 -- Blood-Siegfried, J. and Shelton, B. Animal models of sudden unexplained death. FEMS Immunol Med Microbiol. 42(1); 34-41.
  • 2002 -- PubMed # : 12357040 -- Blood-Siegfried, J. and Nyska, A. and Lieder, H. and Joe, M. and Vega, L. and Patterson, R. and Germolec, D. Synergistic effect of influenza a virus on endotoxin-induced mortality in rat pups: a potential model for sudden infant death syndrome. Pediatr Res. 52(4); 481-90.
  • 2000 -- PubMed # : 11235438 -- Blood-Siegfried, J. Sudden infant death syndrome: a toxic response. AACN Clin Issues. 11(2); 300-8.
  • 2000 -- PubMed # : 11232205 -- Cheek, D. J. and McHugh, J. M. and Blood-Siegfried, J. and McFetridge, J. F. and Turner, B. S. A historical perspective on the discovery of adenyl purines. Biol Res Nurs. 1(4); 265-75.
  • 1998 -- PubMed # : 9475357 -- Blood-Siegfried, J. and Crabb Breen, E. and Takeshita, S. and Martinez-Maza, O. and Vredevoe, D. Monokine production following in vitro stimulation of the THP-1 human monocytic cell line with pertussis vaccine components. J Clin Immunol. 18(1); 81-8.
  • 1998 -- PubMed # : 9495943 -- Blood-Siegfried, J. and Hoey, C. and Matheson, E. The challenges of early discharge. Common newborn problems in the first few weeks of life. Adv Nurse Pract. 6(1); 36-40.
  • 2011 -- PubMed # : 21160437 -- Gura, G. F. and Champagne, M. T. and Blood-Siegfried, J. E. Autism spectrum disorder screening in primary care. J Dev Behav Pediatr. January, 2011 32(1); 48-51.
  • 2011 -- PubMed # : 21930034 -- Tripp, S. B. and Perry, J. T. and Romney, S. and Blood-Siegfried, J. Providers as weight coaches: using practice guides and motivational interview to treat obesity in the pediatric office. J Pediatr Nurs. 26(5); 474-9.
  • 2012 -- Blood-Siegfried, J. and Hawks, S. and Nevidjon, B. and Phillips, B. and Short, N. and Valiga, T. and Vorderstrasse, A. and Wood, K.. and Conrad, R. M. Online Teaching Guide June 4, 2012 .
  • 2012 -- PubMed # : 22845029 -- Saviñon, C. and Taylor, J. S. and Canty-Mitchell, J. and Blood-Siegfried, J. Childhood obesity: Can electronic medical records customized with clinical practice guidelines improve screening and diagnosis? J Am Acad Nurse Pract. August, 2012 24(8); 463-71.
  • 2009 -- Blood-Siegfried, J. How to examine ears in children. [Training Film]. 2009 .
  • 2009 -- Blood-Siegfried, J. Newborn examination for nurse practitioners. [Training Film]. 2009 .
  • 2007 -- Clinton, C. E. (director); Blood-Siegfried, J. E. (actor and hearing moderator) Mock formal harassment complaint hearing. [Training film]. 2007 .
  • 2013 -- PubMed # : 24200295 -- Matheson, E. C. and Derouin, A. and Gagliano, M. and Thompson, J. A. and Blood-Siegfried, J. Increasing HPV vaccination series completion rates via text message reminders. J Pediatr Health Care. November, 2013 28(4); e35-9.
  • 2015 -- PubMed # : 25229995 -- Blood-Siegfried, J. and Zeantoe, G. C. and Evans, L. J. and Bondo, J. and Forstner, J. R. and Wood, K. The Impact of Nurses on Neglected Tropical Disease Management. Public Health Nurs. November, 2015 32(6); 680-701.
  • 2014 -- Blood-Siegfried, J. E. Help fight Ebola without health risks. News and Observer (Raleigh), p. A9. September 17, 2014 .
  • 2014 -- Titch, J. F. and Holsinger, T. and Vacchiano, C., and Blood-Siegfried, J. Improving anesthetic depth assessment during electroconvulsive therapy with bispectral index monitoring: A pilot quality improvement project Anesthesia eJournal. 2014 2(2); .
  • 2015 -- PubMed # : 26212466 -- Eggert, L. K. and Blood-Siegfried, J. and Champagne, M. and Al-Jumaily, M. and Biederman, D. J. Coalition Building for Health: A Community Garden Pilot Project with Apartment Dwelling Refugees. J Community Health Nurs. Jul-Sep, 2015 32(3); 141-50.
  • 2015 -- PubMed # : 25870597 -- Blood-Siegfried, J. Animal models for assessment of infection and inflammation: contributions to elucidating the pathophysiology of sudden infant death syndrome. Front Immunol. March, 2015 6 137.
  • 2014 -- Blood-Siegfried, J.. Animal models of sudden infant death syndrome. 2014 127-140.
  • 2015 -- Cain, S. and Anderson, R. and Stockert, P. and Brown, S. and Blood-Siegfried, J. Intra-operative implementation of a tissue sealant on all lung surgery patients: A quality improvement project, Clinical Scholars Review. May 1, 2015 8(1); 125-129.
Grant Funding (Selected)
  • The Effect of Perinatal Nicotine Exposure on the Development of Autonomic Responses
    National Institutes of Health
    08/2008 to 07/2011
    Role: PI
    Project Goal: Investigate the effect of perinatal nicotine exposure on the development of autonomic responses.
  • CIT Instructional Technology Faculty Fellowship
    Duke University Center for Instructional Technology
    07/2010 to 06/2011
    Role: PI
    Project Goal: Group will define and develop “Best Practices” in both technology and pedagogy to be used for teaching online students and mentoring faculty about online education. The work of the Fellowship will be compiled and published as an “Online teaching orientation guide” for current and future faculty member use in the School of Nursing and other schools and programs at Duke.
  • Effect of maternal nicotine exposure on mortality in suckling rat pups in an infectious model of SIDS
    Duke University School of Nursing
    07/2004 to 06/2005
    Role: PI
    Investigate effect of maternal nicotine exposure on mortality in suckling rat pups in an infectious model of SIDS.
  • Curricular change in online curriculum and technology
    Duke University Center for Instructional Technology
    06/2004 to 05/2005
    Role: PI
    Purpose: A fellowship to support curricular change in online curriculum and technology in the School of Nursing core curriculum. Develop best practices and a rubric for evaluating online coursework.
  • Partners for Quality Education
    Robert Wood Johnson Foundation
    07/2002 to 06/2004
    Role: Team member
    Partners for Quality Education is a grant to develop an interdisciplinary partnership to provide education for multidisciplinary learners in chronic illness care.
  • Combined NNP/PNP Program for Rural Health
    Health Resources and Service Administration (HRSA), Division of Nursing
    07/2001 to 06/2004
    Role: Project Faculty
    Three-year grant to educate nurses at the Master’s level in a combined Neonatal Nurse Practitioner/Pediatric Nurse Practitioner pogram for rural health.
  • Pediatric Acute Care Nurse practitioner
    Health Resources and Service Administration (HRSA) Division of Nursing
    07/1999 to 06/2002
    Role: Project faculty
    A three year grant to educate nurses at the Master’s level.
  • Duke-NIEHS Nurse Fellowship
    National Institute of Environmental Health Sciences
    07/1998 to 06/2000
    Role: PI
    Post doctoral research training.
  • A study of normal cytokine variations in vertically exposed HIV positive and HIV negative infants
    UCLA School of Nursing
    07/1995 to 06/1996
    Role: PI
  • Descriptive study of suspected pertussis vaccine injury
    UCLA School of Nursing
    07/1990 to 06/1991
    Role: PI
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