Paula Tanabe and her team have submitted a NIH R34 application entitled "Comparing Acute Pain Management Protocols for Patients with Sickle Cell Disease." This proposal requests funding for a two-year period with a start date of July 1, 2014.
The goal of this research is to improve emergency department (ED) pain management for adults with sickle cell disease (SCD). Patients present to the ED for treatment of severe, painful vaso-occlusive crisis (VOC). There is no standard, evidence based approach to treating painful VOC.
The purpose of this pilot RCT proposal is to collect the data necessary to design and execute a definitive RCT comparing patient specific protocols to a SCD standard protocol. Study outcomes are to examine the difference in the reduction in pain score from arrival in the ED to discharge (home or hospital admission), hospital admission, and other clinical (i.e., time to pain relief, improvement in pain score, patient satisfaction) and safety (respiratory and hemodynamic) outcomes.
Thank you to all those who gave their time and expertise in guiding the application process as well as to all those who helped to prepare for this submission.