Kathryn Evans Kreider, associate professor, published an article entitled "Blood Pressure Control and the Association with Diabetes Mellitus Incidence: Results from the SPRINT randomized trial" in Hypertension. Co-authors include Christianne L. Roumie, Adriana M. Hung, Gregory B. Russell, Jan Basile, John Nord, Thomas M. Ramsey, Anjay Rastogi, Mary Ellen Sweeney, Leonardo Tamariz, William J. Kostis, Jonathan S. Williams, Athena Zias, William C. Cushman, and for the SPRINT Research Group.

In addition, she also published an article entitled "Standards of Medical Care in Diabetes 2020" in Diabetes Care. Co-authors included members of the PPC, American College of Cardiology, and ADA staff.

Abstract for "Blood Pressure Control and the Association with Diabetes Mellitus Incidence: Results from the SPRINT randomized trial"

The SPRINT (Systolic Blood Pressure Intervention Trial) demonstrated reduced cardiovascular outcomes. We evaluated diabetes mellitus incidence in this randomized trial that compared intensive blood pressure strategy (systolic blood pressure <120 mm Hg) versus standard strategy (<140 mm Hg). Participants were ≥50 years of age, with systolic 130 to 180 mm Hg and increased cardiovascular risk. Participants were excluded if they had diabetes mellitus, polycystic kidney disease, proteinuria >1 g/d, heart failure, dementia, or stroke. Postrandomization exclusions included participants missing blood glucose or ≥126 mg/dL (6.99 mmol/L) or on hypoglycemics. The outcome was incident diabetes mellitus: fasting blood glucose ≥126 mg/dL (6.99 mmol/L), diabetes mellitus self-report, or new use of hypoglycemics. The secondary outcome was impaired fasting glucose (100–125 mg/dL [5.55–6.94 mmol/L]) among those with normoglycemia (<100 mg/dL [5.55 mmol/L]). There were 9361 participants randomized and 981 excluded, yielding 4187 and 4193 participants assigned to intensive and standard strategies. There were 299 incident diabetes mellitus events (2.3% per year) for intensive and 251 events (1.9% per year) for standard, rates of 22.6 (20.2–25.3) versus 19.0 (16.8–21.5) events per 1000 person-years of treatment, respectively (adjusted hazard ratio, 1.19 [95% CI, 0.95–1.49]). Impaired fasting glucose rates were 26.4 (24.9–28.0) and 22.5 (21.1–24.1) per 100 person-years for intensive and standard strategies (adjusted hazard ratio, 1.17 [1.06–1.30]). Intensive treatment strategy was not associated with increased diabetes mellitus but was associated with more impaired fasting glucose. The risks and benefits of intensive blood pressure targets should be factored into individualized patient treatment goals.