Physics Colloquium - The Twisted Genome: How DNA Torsion Shapes Genome Function
Because DNA is a double helix, the molecular machines that read, copy, and package the genome inevitably twist it. Yet the consequences of this twisting have remained difficult to study. To address this challenge, we developed new single-molecule tools to manipulate and measure DNA torsion. These studies reveal that torsional stress is not merely a byproduct of molecular activity but a fundamental regulator of genome function, highlighting the important roles of mechanics and topology in biology.